CDD-3013 (CDD3013)

Chemical Structure : CDD-3013

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货号: PC-27742Not For Human Use, Lab Use Only.

CDD-3013 is a potent and selective inhibitor of c-Jun N-terminal kinase (JNK) with Kd of 0.12/0.72/0.75 nM for JNK1/2/3 respectively, IC50 of 0.15/0.15/0.11 nM in NanoBRET intracellular target engagement assays.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

CDD-3013 is a potent and selective inhibitor of c-Jun N-terminal kinase (JNK) with Kd of 0.12/0.72/0.75 nM for JNK1/2/3 respectively, IC50 of 0.15/0.15/0.11 nM in NanoBRET intracellular target engagement assays.
CDD-3013 (0.1-10 uM) induces dose-dependent reductions in IL1β-mediated phosphorylation of Ser73 (pSer73) and pSer63 JUN phosphorylation in L1β-stimulated 12Z peritoneal endometriotic epithelial cells.
CDD-3013 (5 uM) significantly decreases the expression of MMP3 and IL8 in endometriotic 12Z cells treated with IL1β, with no impact on viability up to 130 uM.
CDD-3013 potently inhibits IL1β-induced expression of IL18, TNC, DUSP8, CREB5, and TRAF1, suppresses inflammatory gene expression in primary derived endometriotic stromal cells.
CDD-3013 (10 mg/kg) reduces lesion number and decreases macrophage infiltration and proliferation in an induced mouse model of endometriosis.

物理化学性质&存储条件

分子量	482.56
分子式	C27H22N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-hydroxy-3-(pyrrolidine-1-carbonyl)phenyl)-4-(1H-pyrrolo[2,3-b]pyridin-5-yl)benzo[b]thiophene-2-carboxamide

参考文献

1. Madasu C, et al. Proc Natl Acad Sci U S A. 2026 Aug 25;123(34):e2607561123.

CDD-3013 (CDD3013)

生物&药学活性

物理化学性质&存储条件

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CDD-3013 (CDD3013)

生物&药学活性

物理化学性质&存储条件

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