CDD-2807 | STK33 inhibitor | Probechem Biochemicals

Chemical Structure : CDD-2807

加入收藏

CDD-2807 (CDD2807)

货号: PC-22383Not For Human Use, Lab Use Only.

CDD-2807 is a highly potent, selective inhibitor of serine/threonine kinase 33 (STK33) with biochemically Kd of 0.02 nM, IC50 of 9.2 nM in NanoBRET assays, induces contraceptive effect.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

CDD-2807 is a highly potent, selective inhibitor of serine/threonine kinase 33 (STK33) with biochemically Kd of 0.02 nM, IC50 of 9.2 nM in NanoBRET assays, induces contraceptive effect.
CDD-2807 displays >9-fold selective STK33 inhibitor versus other kinases, including CLK1/2/4 and RET.
CDD-2807 treatment (50 mg/kg/day) induces a reversible contraceptive effect in mice, could easily cross the blood-testis barrier to cause infertility.
CDD-2807 is an excellent chemical probe that can be used to perform additional safety and toxicological studies in vivo, including analysis in nonhuman primates.

物理化学性质&存储条件

分子量	446.55
分子式	C29H26N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3-([1,1'-biphenyl]-2-ylethynyl)-1H-indazol-5-yl)(2,6-diazaspiro[3.5]nonan-2-yl)methanone

参考文献

1. Ku AF, et al. Science. 2024 May 24;384(6698):885-890.

CDD-2807 (CDD2807)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

CDD-2807 (CDD2807)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.