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首页-小分子抑制剂&激动剂-TGF-beta/Smad-TGF beta Receptor (TGFBR)-CDD-2789
CDD-2789

Chemical Structure : CDD-2789

CAS No.: 3052084-77-9

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CDD-2789 (CDD2789)

货号: PC-23416Not For Human Use, Lab Use Only.

CDD-2789 is a highly potent and selective ALK2 (ACVR1)/ALK1 (ACVRL1) kinases inhibitor with Kd of 2.1/3.9 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

CDD-2789 is a highly potent and selective ALK2 (ACVR1)/ALK1 (ACVRL1) kinases inhibitor with Kd of 2.1/3.9 nM.
CDD-2789 exhibits high selectivity toward ALK2/ALK1 in KINOMEscan analysis and NB K192 assay.
CDD-2789 effectively attenuates activin A and BMP-induced Phosphorylated SMAD1/5 activation in fibroblasts from individuals with FOP in a dose-dependent manner.
CDD-2789 is a valuable tool compound for further investigation of the biological functions of ALK2 and ALK1 and the therapeutic potential of specific inhibition of ALK2.

物理化学性质&存储条件

分子量 466.58
分子式 C26H34N4O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-cyclobutyl-N-(3-(dimethylamino)propyl)-2-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazole-6-carboxamide

参考文献

1. Jimmidi R, et al. Proc Natl Acad Sci U S A. 2024 Nov 19;121(47):e2413108121.

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