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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-JNK-CDD-2728
CDD-2728

Chemical Structure : CDD-2728

CAS No.: 3061749-63-8

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CDD-2728 (CDD2728)

货号: PC-27741Not For Human Use, Lab Use Only.

CDD-2728 is a potent and selective inhibitor of c-Jun N-terminal kinase (JNK) with Kd of 0.31/3.7/1.6 nM for JNK1/2/3 respectively, IC50 of 0.61/0.57/0.53 nM in NanoBRET intracellular target engagement assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

CDD-2728 is a potent and selective inhibitor of c-Jun N-terminal kinase (JNK) with Kd of 0.31/3.7/1.6 nM for JNK1/2/3 respectively, IC50 of 0.61/0.57/0.53 nM in NanoBRET intracellular target engagement assays.
CDD-2728 (10 uM) induces dose-dependent reductions in IL1β-mediated phosphorylation of Ser73 (pSer73) and pSer63 JUN phosphorylation in L1β-stimulated 12Z peritoneal endometriotic epithelial cells.
CDD-2728 (5 uM) significantly decreases the expression of MMP3 and IL8 in endometriotic 12Z cells treated with IL1β, with no impact on viability up to 50 uM.
CDD-2728 potently inhibits IL1β-induced expression of IL18, TNC, DUSP8, CREB5, and TRAF1, suppresses inflammatory gene expression in primary derived endometriotic stromal cells.
CDD-2728 (5-25 mg/kg) reduces lesion number and decreases macrophage infiltration and proliferation in an induced mouse model of endometriosis.

物理化学性质&存储条件

分子量 456.52
分子式 C25H20N4O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3-(dimethylcarbamoyl)-4-hydroxyphenyl)-4-(1H-pyrrolo[2,3-b]pyridin-5-yl)benzo[b]thiophene-2-carboxamide

参考文献

1. Madasu C, et al. Proc Natl Acad Sci U S A. 2026 Aug 25;123(34):e2607561123.

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