CDD-2693 | Ephrin receptor inhibitor | Probechem Biochemicals

Chemical Structure : CDD-2693

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CDD-2693 (CDD2693)

货号: PC-22284Not For Human Use, Lab Use Only.

CDD-2693 (CDD2693) is a potent, selective pan-ephrin receptor kinase (EPH receptor) inhibitor with binding Ki of 4.0/0.81 nM for EPHA2/EPHA4, respectively.

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生物&药学活性

CDD-2693 (CDD2693) is a potent, selective pan-ephrin receptor kinase (EPH receptor) inhibitor with binding Ki of 4.0/0.81 nM for EPHA2/EPHA4, respectively.
CDD-2693 shows nanomolar activity versus EPHA2 (IC50: 461 nM) and EPHA4 (IC50: 40 nM) but is a micromolar inhibitor of SRC, YES, and FGR.
CDD-2693 significantly decreases EFNA5 (ligand) induced phosphorylation of EPHA2/4, decreases 12Z cell viability, and decreases IL-1β-mediated expression of prostaglandin synthase 2 (PTGS2) in 12Z endometriotic epithelial cells.
CDD-2693 decreases expansion of primary endometrial epithelial organoids from patients with endometriosis and decreases Ewing's sarcoma viability.

物理化学性质&存储条件

分子量	489.59
分子式	C29H32FN3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-fluoro-2-(5'-hydroxy-2,2'-dimethyl-[1,1'-biphenyl]-4-carboxamido)-5-methylphenyl)-N-methylpiperidine-4-carboxamide

参考文献

1. Madasu C, et al. Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2322934121.

CDD-2693 (CDD2693)

生物&药学活性

物理化学性质&存储条件

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CDD-2693 (CDD2693)

生物&药学活性

物理化学性质&存储条件

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