CDD-1653 | BMPR2 inhibitor | Probechem Biochemicals

Chemical Structure : CDD-1653

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CDD-1653 (CDD1653)

货号: PC-49710Not For Human Use, Lab Use Only.

CDD-1653 (CDD1653) is a potent, selective inhibitor of BMP type 2 receptor BMPR2 with IC50 of 2.8 nM, >360-fold over ALK1, and is inactive versus all other type 1 and type 2 TGFβ family kinases.

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生物&药学活性

CDD-1653 (CDD1653) is a potent, selective inhibitor of BMP type 2 receptor BMPR2 with IC50 of 2.8 nM, >360-fold over ALK1, and is inactive versus all other type 1 and type 2 TGFβ family kinases.
CDD-1653 inhibited BMP-mediated gene expression in mammalian cell cultures, suppressed BRE-reporter activity in a luciferase reporter (293T-BRE-Luc) assays with IC50 of 6.92 uM.
Pretreatment with CDD-1653 (25 uM) significantly decreased the phosphorylation of SMAD1/5 (pSMAD1/5) in BMP9 stimulation of pSMAD1/5 in HUVECs.
CDD-1653 is not only selective among the TGFβ family but also completely selective against >408 off-target kinases.

物理化学性质&存储条件

分子量	454.51
分子式	C21H22N6O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((5-Methoxy-4-(3-oxo-4-phenylpiperazin-1-yl)pyrimidin-2-yl)amino)benzenesulfonamide

参考文献

1. Ram K Modukuri, et al. J Med Chem. 2023 Jan 31. doi: 10.1021/acs.jmedchem.2c01886.

CDD-1653 (CDD1653)

生物&药学活性

物理化学性质&存储条件

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CDD-1653 (CDD1653)

生物&药学活性

物理化学性质&存储条件

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