CDD-1281 | BMPR2 inhibitor | Probechem Biochemicals

Chemical Structure : CDD-1281

加入收藏

CDD-1281 (CDD1281)

货号: PC-49709Not For Human Use, Lab Use Only.

CDD-1281 (CDD1281) is a potent, selective inhibitor of BMP type 2 receptor BMPR2 with IC50 of 1.2 nM and Kiapp value of 8 nM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

CDD-1281 (CDD1281) is a potent, selective inhibitor of BMP type 2 receptor BMPR2 with IC50 of 1.2 nM and Kiapp value of 8 nM.
CDD-1281 displays high selectivity (>110-fold–>830-fold) over other type 1 and type 2 TGFβ family kinases.
CDD-1281 inhibited BMP-mediated gene expression in mammalian cell cultures, suppressed BRE-reporter activity in a luciferase reporter (293T-BRE-Luc) assays with IC50 of 6.19 uM.
Pretreatment with CDD-1281 (25 uM) significantly decreased the phosphorylation of SMAD1/5 (pSMAD1/5) in BMP9 stimulation of pSMAD1/5 in HUVECs.
CDD-1281 is not only selective among the TGFβ family but also completely selective against >408 off-target kinases.

物理化学性质&存储条件

分子量	489.58
分子式	C30H27N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-Carbamoylbenzyl)-1-cyclopentyl-2-(isoquinolin-6-yl)-1H-benzo[d]imidazole-6-carboxamide

参考文献

1. Ram K Modukuri, et al. J Med Chem. 2023 Jan 31. doi: 10.1021/acs.jmedchem.2c01886.

CDD-1281 (CDD1281)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

CDD-1281 (CDD1281)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.