CDD-1115 | BMPR2 inhibitor | Probechem Biochemicals

Chemical Structure : CDD-1115

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CDD-1115 (CDD1115)

货号: PC-49711Not For Human Use, Lab Use Only.

CDD-1115 (CDD1115) is a potent, selective inhibitor of BMP type 2 receptor BMPR2 with IC50 of 1.8 nM and Kiapp of 6.2 nM.

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生物&药学活性

CDD-1115 (CDD1115) is a potent, selective inhibitor of BMP type 2 receptor BMPR2 with IC50 of 1.8 nM and Kiapp of 6.2 nM.
CDD-1115 showed weak inhibition (>250 nM) of ALK1 and ALK2 (>100-fold over BMPR2) and poor inhibition (>1000 nM) of ALK3, ALK5, ALK6, and TGFBR2 (>555-fold over BMPR2) and was inactive in inhibiting ALK4, ACVR2A, and ACVR2B.
CDD-1115 inhibited BMP-mediated gene expression in mammalian cell cultures, suppressed BRE-reporter activity in a luciferase reporter (293T-BRE-Luc) assays with IC50 of 24.1 uM.
CDD-1115 exhibited poor half-life in mouse and human liver microsomes.

物理化学性质&存储条件

分子量	546.63
分子式	C32H30N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-Carbamoylbenzyl)-2-(isoquinolin-6-yl)-1-((1R,3R)-3-(methylcarbamoyl) cyclopentyl)-1H-benzo[d]imidazole-6-carboxamide

参考文献

1. Ram K Modukuri, et al. J Med Chem. 2023 Jan 31. doi: 10.1021/acs.jmedchem.2c01886.

CDD-1115 (CDD1115)

生物&药学活性

物理化学性质&存储条件

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CDD-1115 (CDD1115)

生物&药学活性

物理化学性质&存储条件

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