CDC14 phosphatase inhibitor 15

Chemical Structure : CDC14 phosphatase inhibitor 15

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货号: PC-22375Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

CDC14 phosphatase inhibitor 15 is a first-in-class, potent, selective, and bioavailable inhibitor of CDC14 phosphatase with IC50 of 93 nM and 220 nM for human CDC14A and CDC14B, respectively, >50-fold selective over other PTPs.
CDC14 phosphatase inhibitor 15 dose-dependently increased both p53 Ser315 phosphorylation and p53 protein levels in U2OS cells
CDC14 phosphatase inhibitor 15 showed no considerable cytotoxic effects across all tested cells at 50 uM.
CDC14 phosphatase inhibitor 15 showed a good PK profile with acceptable exposure and elimination to enable its use as a chemical probe for future in vivo studies.

物理化学性质&存储条件

分子量	400.32
分子式	C21H15F2O4P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(difluoro(4-(1-phenylvinyl)dibenzo[b,d]furan-1-yl)methyl)phosphonic acid

参考文献

1. Dong J, et al. J Med Chem. 2024 May 20. doi: 10.1021/acs.jmedchem.4c00149.