CD80 inhibitor 6 | CD80 inhibitor | Probechem Biochemicals

Chemical Structure : CD80 inhibitor 6

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CD80 inhibitor 6 (CD80-IN-6)

货号: PC-22887Not For Human Use, Lab Use Only.

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生物&药学活性

CD80 inhibitor 6 is a specific small molecule inhibitor of human CD80 with SPR KD of 2.7 nM, antagonize CD28 (TR_FRET EC50=2.4 nM) and CTLA-4 binding to CD80, inhibits the release of the proinflammatory cytokines IL-2, IFNγ, and TNFα at submicromolar doses in T cell costimulation assays.
CD80 inhibitor 6 binds specifically to human CD80 but not the related protein, human CD86, nor human CD28-Fc, nor do the compounds bind mouse, rat, or canine CD80.
CD80 inhibitor 6 inhibits IL-2 secretion in the CD4+ T cell assay with IC50 of 0.75 uM in purified peripheral blood CD4+ primary T cells.
CD80 inhibitor 6 also inhibits TNFα and IFNγ secretion with IC50 values of 0.97 μM and 0.15 μM, respectively.

物理化学性质&存储条件

分子量	480.52
分子式	C25H26F2N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(cyclohexylamino)propyl)-4-(6,9-difluoro-3-oxo-3,5-dihydro-2H-pyrazolo[4,3-c]cinnolin-2-yl)benzamide

参考文献

1. Philip Huxley, et al. Chem Biol. 2004 Dec;11(12):1651-8.

CD80 inhibitor 6 (CD80-IN-6)

生物&药学活性

物理化学性质&存储条件

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CD80 inhibitor 6 (CD80-IN-6)

生物&药学活性

物理化学性质&存储条件

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