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CD80 inhibitor 1

Chemical Structure : CD80 inhibitor 1

CAS No.: 486449-65-4

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CD80 inhibitor 1 (CD80-IN-1)

货号: PC-22886Not For Human Use, Lab Use Only.

CD80 inhibitor 1 is a specific small molecule inhibitor of human CD80 with SPR KD of 125 nM, antagonize CD28 (TR_FRET EC50=630 nM) and CTLA-4 binding to CD80, inhibits the release of the proinflammatory cytokines IL-2, IFNγ, and TNFα at submicromolar doses in T cell costimulation assays.

规格 价格 库存 数量
5 mg ￥1580 In stock
10 mg ￥2380 In stock
25 mg ￥3880 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CD80 inhibitor 1 is a specific small molecule inhibitor of human CD80 with SPR KD of 125 nM, antagonize CD28 (TR_FRET EC50=630 nM) and CTLA-4 binding to CD80, inhibits the release of the proinflammatory cytokines IL-2, IFNγ, and TNFα at submicromolar doses in T cell costimulation assays.

物理化学性质&存储条件

分子量 323.28
分子式 C17H10FN3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(6-Fluoro-3-oxo-3,5-dihydro-2H-pyrazolo[4,3-c]quinolin-2-yl)benzoic acid

参考文献

1. Philip Huxley, et al. Chem Biol. 2004 Dec;11(12):1651-8.

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