CD 437 |CAS:125316-60-1 Probechem Biochemicals

Chemical Structure : CD 437

CAS No.: 125316-60-1

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CD 437 (CD437)

货号: PC-62291Not For Human Use, Lab Use Only.

CD437 (CD 437) is a retinoid-like small molecule that selectively induces apoptosis in cancer cells, but not in normal cells, directly inhibits DNA polymerase α with IC50 of 22 nM, also acts as an RARγ agonist.

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生物&药学活性

CD437 (CD 437) is a retinoid-like small molecule that selectively induces apoptosis in cancer cells, but not in normal cells, directly inhibits DNA polymerase α with IC50 of 22 nM, also acts as an RARγ agonist.
CD437 shows weak activity against POLA1 L700S or the L764S mutation (IC50:1.2 uM, 2.6 uM, rspectively).
CD437 inhibits the growth of both ATRA-sensitive (CA-OV-3) and ATRA-resistant (SK-OV-3) ovarian tumor cells, and induces apoptosis.

物理化学性质&存储条件

分子量	398.5
分子式	C27H26O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(4-hydroxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid

参考文献

1. Han T, et al. Nat Chem Biol. 2016 Jul;12(7):511-5.

2. Holmes WF, et al. J Cell Biochem. 2003 May 15;89(2):262-78.

3. Mologni L, et al. Blood. 1999 Feb 1;93(3):1045-61.

4. Benedetti L, et al. Blood. 1996 Mar 1;87(5):1939-50.

CD 437 (CD437)

生物&药学活性

物理化学性质&存储条件

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CD 437 (CD437)

生物&药学活性

物理化学性质&存储条件

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