CD147 inhibitor AC-73 | CD147 inhibitor | Probechem Biochemicals

Chemical Structure : CD147 inhibitor AC-73

CAS No.: 775294-71-8

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CD147 inhibitor AC-73 (AC-73)

货号: PC-49041Not For Human Use, Lab Use Only.

AC-73 is a potent, specific small molecule inhibitor of CD147 (Response Units=63, SPR assays), AC-73 disrupts CD147 dimerization and inhibits the motility and invasion of hepatocellular carcinoma cells.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

AC-73 is a potent, specific small molecule inhibitor of CD147 (Response Units=63, SPR assays), AC-73 disrupts CD147 dimerization and inhibits the motility and invasion of hepatocellular carcinoma cells.
AC-73 significantly decreased the migration ability of SMMC-7721 cells in a dose-dependent manner in in vitro scratch assays, decreased the invasion of HCC cells with IC50 of 10.19 μM for SMMC-7721 and 7.16 μM for Huh-7, respectively.
AC-73 inhibits the invasion of HCC cells by reducing MMP-2 production through blocking CD147-stimulated MAPK/STAT3 signaling.
AC-73 (25 mg/kg, 50 mg/kg, intrahepatic injection) reduced tumor metastasis by affecting the CD147/ERK1/2/STAT3 pathways in orthotopic HCC transplant nude mouse model, with low toxicity and well tolerance in nude mice.
AC-73 likely binds to the dimer interface of CD147, the N-terminal IgC2 domain of CD147.

物理化学性质&存储条件

分子量	319.4
分子式	C21H21NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-{2-[(Biphenyl-4-ylmethyl)-amino]-1-hydroxy-ethyl}-phenol

参考文献

1. Spinello I, et al. Haematologica. 2019 May;104(5):973-985.

2. Fu ZG, et al. Oncotarget. 2016 Feb 23;7(8):9429-47.

CD147 inhibitor AC-73 (AC-73)

生物&药学活性

物理化学性质&存储条件

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CD147 inhibitor AC-73 (AC-73)

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物理化学性质&存储条件

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