CD12681 |CAS:1952239-59-6 Probechem Biochemicals

Chemical Structure : CD12681

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CD12681 (CD-12681;CD 12681)

货号: PC-35306Not For Human Use, Lab Use Only.

CD12681 (CD-12681) is a potent, selective RORγ inverse agonist with IC50 of 19 nM, displays no activity against a panel of nuclear receptors (RORα, RARγ, LXRβ, PPARγ and VDR).

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生物&药学活性

CD12681 (CD-12681) is a potent, selective RORγ inverse agonist with IC50 of 19 nM, displays no activity against a panel of nuclear receptors (RORα, RARγ, LXRβ, PPARγ and VDR).
CD12681 inhibits IL17 production in stimulated CD4 in human hepatocytes with IC50 of 10 nM.
CD12681 inhibits ear swelling and IL-17 cell recruitment induced by IL-23 in mice model.
CD12681 is a selective RORγ inverse agonist is sufficient to modulate an IL-23/IL-17-mediated skin inflammation.

物理化学性质&存储条件

分子量	471.616
分子式	C25H33N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2,4-dimethylphenyl)-N-isobutyl-2-oxo-1-[(tetrahydro-2H-pyran-4-yl)methyl]-2,3-dihydro-1H-benzo[d]imidazole-5-sulfonamide

参考文献

1. Baffert F, et al. Mol Cancer Ther. 2010 Jul;9(7):1945-55.

2. Ringel F, et al. Acta Haematol. 2014;132(1):75-86.

3. Cheon JH, et al. Biochem Biophys Res Commun. 2017 Sep 2;490(4):1176-1182.

4. Haissaguerre M, et al. Front Pharmacol. 2018 May 15;9:527.

CD12681 (CD-12681;CD 12681)

生物&药学活性

物理化学性质&存储条件

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CD12681 (CD-12681;CD 12681)

生物&药学活性

物理化学性质&存储条件

参考文献

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