CCX662 (CCX-662)

Chemical Structure : CCX662

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货号: PC-28385Not For Human Use, Lab Use Only.

CCX662 (CCX-662) is a potent, selective CXCR7 (ACKR3) inhibitor with IC50 of 9 nM (buffer) and 18 nM (100% human serum), and rat IC50 of 14 nM (100% rat serum), blocks CXCL12 binding to CXCR7, inhibits CXCR4-directed trans-endothelial migration of CXCR4+/CXCR7+ cells.

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生物&药学活性

CCX662 (CCX-662) is a potent, selective CXCR7 (ACKR3) inhibitor with IC50 of 9 nM (buffer) and 18 nM (100% human serum), and rat IC50 of 14 nM (100% rat serum), blocks CXCL12 binding to CXCR7, inhibits CXCR4-directed trans-endothelial migration of CXCR4+/CXCR7+ cells.

物理化学性质&存储条件

分子量	539.69
分子式	C28H37N5O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Butanoic acid, 4-[[8-[hexahydro-4-[[2-(4-hydroxy-1-piperidinyl)-4-thiazolyl]methyl]-1H-1,4-diazepin-1-yl]-6-methyl-7-quinolinyl]oxy]-

参考文献

1. Patent WO2010/054006 A1.

2. Walters MJ, et al. Br J Cancer. 2014;110(5):1179-1188.

CCX662 (CCX-662)

生物&药学活性

物理化学性质&存储条件

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CCX662 (CCX-662)

生物&药学活性

物理化学性质&存储条件

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