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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-CCX140
CCX140

Chemical Structure : CCX140

CAS No.: 1100318-47-5

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CCX140 (Ilacirnon, CCX-140, CCX140B)

货号: PC-42417Not For Human Use, Lab Use Only.

CCX140 (Ilacirnon, CCX140B) is a potent, selective, orally bioavailable CCR2 antagonist with Kd of 2.3 nM for hCCR2.

规格 价格 库存 数量
5 mg ￥680 In stock
10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2480 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CCX140 (Ilacirnon, CCX140B) is a potent, selective, orally bioavailable CCR2 antagonist with Kd of 2.3 nM for hCCR2.
CCX140 (CCX140B) displays little to no activity against 142 various biologically important receptor, no effect on plasma levels of the CCR2 ligand CCL2 or on the numbers of blood monocytes.
CCX140 (CCX140B) potently inhibits CCL2-induced chemotaxis of purified human blood monocytes with IC50 of 8 nM, also inhibits CCL2-induced Ca2+ mobilization in monocytes with IC50 of 3 nM.
CCX140 (CCX140B) decreases levels of fasting blood glucose and improves insulin sensitivity in mice.

物理化学性质&存储条件

分子量 495.8621296
分子式 C20H13ClF3N5O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzenesulfonamide, 4-chloro-N-[5-methyl-2-(7H-pyrrolo[2,3-d]pyrimidin-4-ylcarbonyl)-3-pyridinyl]-3-(trifluoromethyl)-

参考文献

1. Sullivan TJ, et al. J Pharmacol Exp Ther. 2012 Jun 5. doi: 10.1124/jpet.111.190918.

2. Sullivan TJ, et al. Metabolism. 2013 Nov;62(11):1623-32.

3. Sullivan T, et al. Am J Physiol Renal Physiol. 2013 Nov 1;305(9):F1288-97.

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