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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-CCX-771
CCX-771

Chemical Structure : CCX-771

CAS No.: N/A

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CCX-771 (CCX 771;CCX771)

货号: PC-60212Not For Human Use, Lab Use Only.

CCX-771 is a potent, selective CXCR7 antagonist with IC50 of 4.1 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

CCX-771 is a potent, selective CXCR7 antagonist with IC50 of 4.1 nM.
CCX-771 potently inhibits CXCL12-induced NC-37 cell transendothelial migration (TEM) with IC50 of 49 nM, 20 times greater than that of AMD3100 (IC50=830 nM).
CCX-771 also potently stimulates β-arrestin2 recruitment to CXCR7, with greater potency and efficacy than the endogenous chemokine ligands.
CCX-771 inhibits lesion formation and ameliorates hyperlipidemia after vascular injury and during atherosclerosis in Apoe(-/-) mice.

物理化学性质&存储条件

分子量
分子式
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Zabel BA, et al. J Immunol. 2009, 183(5), 3204-3211.

2. Li X, et al. Circulation. 2014 Mar 18;129(11):1244-53.

3. Yamada K, et al. Int J Cancer. 2015 Dec 15;137(12):2825-36.

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