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首页-小分子抑制剂&激动剂-Apoptosis-Bcl-2-CCT369347
CCT369347

Chemical Structure : CCT369347

CAS No.: 2253786-82-0

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CCT369347 (CCT-369347)

货号: PC-72519Not For Human Use, Lab Use Only.

CCT369347 (CCT-369347) is potent selective inhibitor of BCL-6 with TR-FRET IC50 of 26 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CCT369347 (CCT-369347) is potent selective inhibitor of BCL-6 with TR-FRET IC50 of 26 nM.
    CCT369347 demonstrated antiproliferative activity in a panel of BCL6-positive lymphoma cell lines (OCI-Ly1, SU-DHL-4, and SU-DHL-6) with IC50 of 1.68-3.45 uM, with weaker activity against low BCL6 expression cells and noncytotoxocity.
    CCT369347 inhibits BCL6 in a cellular assay with a submicromolar IC50 and shows promising early PK.

    物理化学性质&存储条件

    分子量 485.976
    分子式 C26H24ClN7O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-Chloro-4-((4-((2-(5-cyclopropylpyrimidin-2-yl)propan-2-yl)amino)-1-methyl-2-oxo-1,2-dihydroquinolin-6-yl)amino)nicotinonitrile

    参考文献

    1. Matthew G Lloyd, et al. J Med Chem. 2021 Dec 9;64(23):17079-17097.

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