CCT369260 | BCL6 degrader | Probechem Biochemicals

Chemical Structure : CCT369260

CAS No.: 2253878-44-1

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CCT369260 (CCT 369260)

货号: PC-38808Not For Human Use, Lab Use Only.

CCT369260 is a highly potent, orally active BCL6 degrader with DC50 of 54 nM in cellular BCL6 degradation assays.

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2 mg	￥2280	In stock
5 mg	￥3880	In stock
10 mg	￥5980	In stock
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50 mg		Get quote
100 mg		Get quote

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生物&药学活性

CCT369260 is a highly potent, orally active BCL6 degrader with DC50 of 54 nM in cellular BCL6 degradation assays.
CCT369260 exhibits an IC50 of 523 nM in BCL6 TR-FRET assays.
CCT369260 showed robust antiproliferative activity in SU-DHL-4 cells, with no antiproliferative activty in a panel of BCL6-negative cell lines.
CCT369260 (50 mg/kg) reduces BCL6 levels in a lymphoma xenograft mouse model following oral dosing.

物理化学性质&存储条件

分子量	508.999
分子式	C24H31ClF2N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((5-chloro-2-((3R,5S)-4,4-difluoro-3,5-dimethylpiperidin-1-yl)pyrimidin-4-yl)amino)-3-(3-hydroxy-3-methylbutyl)-1-methyl-1,3-dihydro-2H-benzo[d]imidazol-2-one

参考文献

1. Bellenie BR, et al. J Med Chem. 2020 Apr 23;63(8):4047-4068.

2. Rosemary Huckvale, et al. J Med Chem. 2022 Jun 2. doi: 10.1021/acs.jmedchem.1c02175.

CCT369260 (CCT 369260)

生物&药学活性

物理化学性质&存储条件

参考文献

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CCT369260 (CCT 369260)

生物&药学活性

物理化学性质&存储条件

参考文献

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