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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Heat Shock Protein (HSP)-CCT251236
CCT251236

Chemical Structure : CCT251236

CAS No.: 1693731-40-6

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CCT251236 (CCT-251236)

货号: PC-60233Not For Human Use, Lab Use Only.

CCT251236 (CCT-251236) is a potent, orally available Pirin ligand (Ki=28 nM), blocks the HSF1-mediated induction of both HSP72 and HSP27.

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10 mg ￥1980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CCT251236 (CCT-251236) is a potent, orally available Pirin ligand (Ki=28 nM), blocks the HSF1-mediated induction of both HSP72 and HSP27.
CCT251236 inhibits the induction of HSP72 at the mRNA level, blocks the induction of HSPA1A gene expression with IC50 of 40 nM, inhibits SK-OV-3 cells proliferation with GI50 of 1.1 nM.
CCT251236 displays efficacy in a human ovarian carcinoma xenograft model.

物理化学性质&存储条件

分子量 552.631
分子式 C32H32N4O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide

参考文献

1. Cheeseman MD, et al. J Med Chem. 2017 Jan 12;60(1):180-201.

2. Chessum NEA, et al. J Med Chem. 2017 Dec 14. doi: 10.1021/acs.jmedchem.7b01406.

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