CCT245718 | Aurora A/FLT3 inhibitor | Probechem Biochemicals

Chemical Structure : CCT245718

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CCT245718 (CCT-245718)

货号: PC-72759Not For Human Use, Lab Use Only.

CCT245718 is a potent, dual Aurora A/FLT3 inhibitor with Kd of 39 nM (FLT3 D835Y) and 170 nM (FLT3 ITD), IC50 of 15 nM (Aurora A).

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生物&药学活性

CCT245718 is a potent, dual Aurora A/FLT3 inhibitor with Kd of 39 nM (FLT3 D835Y) and 170 nM (FLT3 ITD), IC50 of 15 nM (Aurora A).
CCT245718 weakly inhibits Aurora B with IC50 of 3045 nM.
CCT245718 exhibits potent antiproliferative activity towards FLT3-ITD + AML cell lines and strongly binds to FLT3-ITD and TKD (D835Y) mutants in vitro.
CCT245718 reduces phosphorylation of STAT5, downregulation of survivin and induces apoptotic cell death.
CCT245718 overcomes TKD-mediated resistance in a MOLM-13-derived cell line containing FLT3 with both ITD and D835Y mutations.

物理化学性质&存储条件

分子量	436.900
分子式	C22H21ClN6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility
Chemical Name/SMILES

参考文献

1. Tariq MU, et al. Br J Cancer. 2021 Sep;125(7):966-974.

CCT245718 (CCT-245718)

生物&药学活性

物理化学性质&存储条件

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CCT245718 (CCT-245718)

生物&药学活性

物理化学性质&存储条件

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