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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Checkpoint Kinase (Chk)-CCT241533
CCT241533

Chemical Structure : CCT241533

CAS No.: 1262849-73-9

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CCT241533 (CCT 241533;CCT-241533)

货号: PC-44032Not For Human Use, Lab Use Only.

CCT241533 is a potent and selective ATP-competitive inhibitor of CHK2 with IC50 of 3 nM.

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5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3280 In stock
50 mg ￥5280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CCT241533 is a potent and selective ATP-competitive inhibitor of CHK2 with IC50 of 3 nM.
CCT241533 shows good selectivity for CHK2 against CHK1 (IC50=180 nM) and a wider panel of kinases and with promising in vitro ADMET properties.
CCT241533 inhibits CHK2 autophosphorylation at S516, band shift mobility changes, and HDMX degradation.

物理化学性质&存储条件

分子量 442.4833
分子式 C23H27FN4O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
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Solubility

10 mM in DMSO
Chemical Name/SMILES

3-Pyrrolidinemethanol, 4-[[2-(5-fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-α,α-dimethyl-, (3R,4S)-

参考文献

1. Caldwell JJ, et al. J Med Chem. 2011 Jan 27;54(2):580-90.

2. Anderson VE, et al. Cancer Res. 2011 Jan 15;71(2):463-72.

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