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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Heat Shock Protein (HSP)-CCT018159
CCT018159

Chemical Structure : CCT018159

CAS No.: 171009-07-7

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CCT018159 (CCT-018159, CCT 018159)

货号: PC-61633Not For Human Use, Lab Use Only.

CCT018159 is al potent inhibitor of Hsp90 ATPase activity with IC50 of 7.1 uM, also inhibits the ATPase activity of R-loop unwinding helicase DDX39B (UAP56).

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5 mg ￥880 In stock
10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CCT018159 is al potent inhibitor of Hsp90 ATPase activity with IC50 of 7.1 uM, also inhibits the ATPase activity of R-loop unwinding helicase DDX39B (UAP56).
CCT018159 inhibits recombinant UAP56 ATPase activity with Ki of 5.5 uM, reduces UAP56 activity by >70% at 100 µM (IC50=64.3 uM).
CCT018159 disrupts vRNP formation without inhibiting cellular mRNA export.
CCT018159 prevents KSHV lytic replication.
CCT018159 shows a mean cellular GI50 of 5.3 uM across a panel of human cancer cell lines.
CCT018159 causes cell cytostasis associated with a G(1) arrest and induces apoptosis, also inhibites key endothelial and tumor cell functions implicated in invasion and angiogenesis.

物理化学性质&存储条件

分子量 352.39
分子式 C20H20N2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]-6-ethyl-1,3-benzenediol

参考文献

1. Jing R, et al. Development. 2017 May 15;144(10):1764-1774.

2. Sharp SY, et al. Cancer Res. 2007 Mar 1;67(5):2206-16.

3. Schumann S, et al. Nat Microbiol. 2016 Oct 31;2:16201.

4. Beloueche-Babari M, et al. Oncotarget. 2010 Jul;1(3):185-97.

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