CCT-251455 |CAS:1400284-80-1 Probechem Biochemicals

Chemical Structure : CCT-251455

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CCT-251455 (CCT 251455;CCT251455)

货号: PC-61144Not For Human Use, Lab Use Only.

CCT-251455 is a potent, selective, orally active monopolar spindle 1 (MPS1) inhibitor with IC50 of 3 nM, with no activity for CDK2 and Aurora A (IC50>40 uM).

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1 g		Get quote

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生物&药学活性

CCT-251455 is a potent, selective, orally active monopolar spindle 1 (MPS1) inhibitor with IC50 of 3 nM, with no activity for CDK2 and Aurora A (IC50>40 uM).
CCT-251455 stabilizes an inactive conformation of MPS1 with the activation loop ordered in a manner incompatible with ATP and substrate-peptide binding.
CCT-251455 inhibits HCT116 cell growth with GI50 of 0.16 uM, dose-dependently inhibits MPS1 in HCT116 human tumor xenograft model.

物理化学性质&存储条件

分子量	503.991
分子式	C26H26ClN7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	tert-Butyl 6-(2-Chloro-4-(1-methyl-1H-imidazol-5-yl) phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1Hpyrrolo[3,2-c]pyridine-1-carboxylate

参考文献

1. Naud S, et al. J Med Chem. 2013 Dec 27;56(24):10045-65.

2. Gurden MD, et al. Cancer Res. 2015 Aug 15;75(16):3340-54.

CCT-251455 (CCT 251455;CCT251455)

生物&药学活性

物理化学性质&存储条件

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CCT-251455 (CCT 251455;CCT251455)

生物&药学活性

物理化学性质&存储条件

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