CCT-031374 hydrobromide |CAS:1219184-91-4 Probechem Biochemicals

Chemical Structure : CCT-031374 hydrobromide

CAS No.: 1219184-91-4

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CCT-031374 hydrobromide (CCT031374 hydrobromide)

货号: PC-61321Not For Human Use, Lab Use Only.

A novel small-molecule Wnt signaling inhibitor that inhibits TCF-dependent transcription with IC50 of 6.1 uM in 7dF3 reporter assay.

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5 mg	￥2480	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

CCT031374 hydrobromide is a novel small-molecule Wnt signaling inhibitor that inhibits TCF-dependent transcription with IC50 of 6.1 uM in 7dF3 reporter assay.
CCT-031374 hydrobromide promotes β-catenin degradation and lowers β-catenin levels in mouse L-cells, blockes the growth of a number of cancer cell lines including SW480 colon cancer cells (IC50=13.2 uM).
CCT-031374 hydrobromide blocks free β-catenin levels in BIO-stimulated HEK293 cells.

物理化学性质&存储条件

分子量	434.33
分子式	C23H19N3O.HBr
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-([1,1'-biphenyl]-4-yl)-2-(2,3-dihydro-9H-benzo[d]imidazo[1,2-a]imidazol-9-yl)ethan-1-one hydrochloride

参考文献

1. Ewan K, et al. Cancer Res. 2010 Jul 15;70(14):5963-73.

2. Yang Y, et al. Neuroscience. 2013 Sep 17;248:383-91.

3. Liu B, et al. Int J Mol Med. 2015 Dec;36(6):1572-82.

CCT-031374 hydrobromide (CCT031374 hydrobromide)

生物&药学活性

物理化学性质&存储条件

参考文献

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CCT-031374 hydrobromide (CCT031374 hydrobromide)

生物&药学活性

物理化学性质&存储条件

参考文献

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