CCT-031374 |CAS:442535-46-8 Probechem Biochemicals

Chemical Structure : CCT-031374

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CCT-031374 (CCT031374)

货号: PC-62168Not For Human Use, Lab Use Only.

CCT-031374 (CCT031374) is a selective β-catenin signaling inhibitor with IC50 of 6.1 uM.

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生物&药学活性

CCT-031374 (CCT031374) is a selective β-catenin signaling inhibitor with IC50 of 6.1 uM.
CCT-031374 prevents BIO-induced accumulation of β-catenin, does not alter β-catenin levels but blocks transcription at the β-catenin level。
CCT-031374 also shows activity against endogenous LEF-1 mRNA levels in human neurogenic embryoid bodies (hNEBs) in which Wnt signaling had been induced by BIO.

物理化学性质&存储条件

分子量	353.425
分子式	C23H19N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)ethanone

参考文献

1. Ewan K, et al. Cancer Res. 2010 Jul 15;70(14):5963-73.

2. Yang Y, et al. Neuroscience. 2013 Sep 17;248:383-91.

3. Liu B, et al. Int J Mol Med. 2015 Dec;36(6):1572-82.

CCT-031374 (CCT031374)

生物&药学活性

物理化学性质&存储条件

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CCT-031374 (CCT031374)

生物&药学活性

物理化学性质&存储条件

参考文献

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