CCR7 inhibitor Cmp1205 | CCR7 inhibitor | Probechem Biochemicals

Chemical Structure : CCR7 inhibitor Cmp1205

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CCR7 inhibitor Cmp1205 (Cmp2105)

货号: PC-73250Not For Human Use, Lab Use Only.

CCR7 inhibitor Cmp1205 is an allosteric ligand and antagonist for human CC chemokine receptor 7 (CCR7) with Kd of 3 nM, suppresses arrestin binding in response to activation by CCL19 with IC50 of 7.3 uM.

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生物&药学活性

CCR7 inhibitor Cmp1205 is an allosteric ligand and antagonist for human CC chemokine receptor 7 (CCR7) with Kd of 3 nM, suppresses arrestin binding in response to activation by CCL19 with IC50 of 7.3 uM.
Cmp1205 binds to a pocket at the intracellular part of CCR7 between the ends of TM1, TM2, TM3, and TM6 and the loop between TM7 and H8.
Cmp1205 allosterically inhibits binding of the native chemokine CCL19 ligand in a membrane-based competition binding experiment with IC50 of 35 nM.

物理化学性质&存储条件

分子量	475.56
分子式	C22H29N5O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, 3-[[4-[[(1R)-2,2-dimethyl-1-(5-methyl-2-furanyl)propyl]amino]-1,1-dioxido-1,2,5-thiadiazol-3-yl]amino]-2-hydroxy-N,N,6-trimethyl-

参考文献

1. Kathrin Jaeger, et al. Cell. 2019 Aug 22;178(5):1222-1230.e10.

2. Proj M, et al. Front Pharmacol. 2022 Mar 18;13:855653.

CCR7 inhibitor Cmp1205 (Cmp2105)

生物&药学活性

物理化学性质&存储条件

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CCR7 inhibitor Cmp1205 (Cmp2105)

生物&药学活性

物理化学性质&存储条件

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