CCR6 inhibitor 35

Chemical Structure : CCR6 inhibitor 35

CAS No.: 2437547-04-9

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货号: PC-35572Not For Human Use, Lab Use Only.

CCR6 inhibitor 35 is a potent and selective CCR6 inhibitor with IC50 of 6.0 nM (hCCR6).

规格	价格	库存
5 mg	￥2480	In stock
10 mg	￥4280	In stock
25 mg	￥7280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

CCR6 inhibitor 35 is a potent and selective CCR6 inhibitor with IC50 of 6.0 nM (hCCR6).
CCR6 inhibitor 35 exhibits potent activity in the migration assay as well as the Gi signal assay with IC50 of <30 nM and 6 nM in human CCR6-transfected CHO cells, respectively, and displays high human CCR6 selectivity over human CCR1 and CCR7.
CCR6 inhibitor 35 potently inhibits CCR6-dependent cell migration and the increase in ERK phosphorylation in human primary cells.

物理化学性质&存储条件

分子量	504.528
分子式	C24H23F3N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-(((1r,4r)-4-((5-(trifluoromethyl)pyridin-2-yl)amino)cyclohexyl)sulfonyl)phenyl)picolinamide

参考文献

1. Tawaraishi T, et al. Bioorg Med Chem Lett. 2018 Jul 30. pii: S0960-894X(18)30637-1.