CCI-007 |CAS:939228-52-1 Probechem Biochemicals

Chemical Structure : CCI-007

CAS No.: 939228-52-1

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CCI-007 (CCI007; CCI 007)

货号: PC-36025Not For Human Use, Lab Use Only.

CCI-007 (CCI 007) is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia with IC50 of 3.5 uM against MLL-r leukemia cell line PER-485.

规格	价格	库存
10 mg	￥1980	In stock
25 mg	￥2980	In stock
100 mg	￥6980	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

CCI-007 (CCI 007) is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia with IC50 of 3.5 uM against MLL-r leukemia cell line PER-485.
CCI-007 induced a rapid caspase-dependent apoptosis with mitochondrial depolarization within 24h treatment.
CCI-007 altered the characteristic MLL-r gene expression signature in sensitive cells with downregulation of the expression of HOXA9, MEIS1, CMYC and BCL2, important drivers in MLL-r leukemia.

物理化学性质&存储条件

分子量	336.362
分子式	C15H16N2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Ethyl-2-(4-((2-imino-4-oxothiazolidin-5-ylidene)methyl)-2-methoxyphenoxy)acetate

参考文献

1. Somers K, et al. Oncotarget. 2016 Jul 19;7(29):46067-46087.

CCI-007 (CCI007; CCI 007)

生物&药学活性

物理化学性质&存储条件

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CCI-007 (CCI007; CCI 007)

生物&药学活性

物理化学性质&存储条件

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