CCG258747

Chemical Structure : CCG258747

CAS No.: 2615910-00-2

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货号: PC-23973Not For Human Use, Lab Use Only.

CCG258747 is a potent selective GRK2 inhibitor with IC50 of 18 nM, 83-fold selectivity over GRK5.

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2 mg	￥2580	In stock
5 mg	￥4580	In stock
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100 mg		Get quote

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生物&药学活性

CCG258747 is a potent selective GRK2 inhibitor with IC50 of 18 nM, 83-fold selectivity over GRK5.
CCG258747 is selective against GRK1 and PKA and shows little inhibition against ROCK1 at 10 µM.
CCG258747 demonstrated robust efficacy in blocking receptor internalization in HEK293 cells.
CCG258747 reduced MOR phosphorylation of Ser375 in pSer375-MOR for both HEK293 and U2OS stable cells.

物理化学性质&存储条件

分子量	502.55
分子式	C28H27FN4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, 5-[(3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-piperidinyl]-2-fluoro-N-(1H-indazol-3-ylmethyl)-

参考文献

1. Bouley RA, et al. Mol Pharmacol. 2020 Jun;97(6):392-401.

CCG258747

生物&药学活性

物理化学性质&存储条件

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CCG258747

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物理化学性质&存储条件

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