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CCG257081

Chemical Structure : CCG257081

CAS No.: 1922098-90-5

CCG257081 (CCG-257081)

货号: PC-23604Not For Human Use, Lab Use Only.

CCG-257081 is a small molecule MRTF/SRF pathway inhibitor, shows direct binding to pirin with ITC KD value of 8.6 uM, inhibits melanoma metastasis and bleomycin-induced fibrosis.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

CCG-257081 is a small molecule MRTF/SRF pathway inhibitor, shows direct binding to pirin with ITC KD value of 8.6 uM, inhibits melanoma metastasis and bleomycin-induced fibrosis.

物理化学性质&存储条件

分子量 473.88
分子式 C24H19ClF3N3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(4-chlorophenyl)-5,5-difluoro-1-(3-fluoro-5-(pyridin-4-yl)benzoyl)piperidine-3-carboxamide

参考文献

1. Erika M Lisabeth, et al. ACS Pharmacol Transl Sci. 2019 Apr 12;2(2):92-100.

2. Panesso-Gómez S, et al. bioRxiv [Preprint]. 2024 Nov 17:2024.11.15.623825.

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