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首页-小分子抑制剂&激动剂-Others-GRK (GPCRK)-CCG-224406
CCG-224406

Chemical Structure : CCG-224406

CAS No.: 1870843-22-3

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CCG-224406 (CCG 224406;CCG224406)

货号: PC-70119Not For Human Use, Lab Use Only.

CCG-224406 (CCG224406) is a highly selective and potent GRK2 (G protein-coupled receptor kinase 2) inhibitor with IC50 of 130 nM.M.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CCG-224406 (CCG224406) is a highly selective and potent GRK2 (G protein-coupled receptor kinase 2) inhibitor with IC50 of 130 nM.
    CCG-224406 displays >700-fold selectivity over other GRK subfamilies, and no detectable inhibition of ROCK1.

    物理化学性质&存储条件

    分子量 558.57
    分子式 C29H27FN6O5
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(3-((2,6-dimethoxybenzyl)carbamoyl)-4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

    参考文献

    1. Waldschmidt HV, et al. J Med Chem. 2016 Apr 28;59(8):3793-807.

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