CCG-222740 |CAS:1922098-69-8 Probechem Biochemicals

Chemical Structure : CCG-222740

CAS No.: 1922098-69-8

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CCG-222740 (CCG222740)

货号: PC-35330Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥2480	In stock
10 mg	￥3980	In stock
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

CCG-222740 (CCG222740) is a pharmacological inhibitor of MRTF/SRF signalling, shows greater inhibitory effect on MRTF/SRF target genes than MRTF-A inhibitor CCG-203971, with IC50 of 5 uM in fibroblast-mediated collagen contraction assay.
CCG-222740 is a more potent inhibitor of alpha-smooth muscle actin protein expression than CCG-203971.
CCG-222740 prevents scar tissue formation in a preclinical model of fibrosis; effectively kills BRAFi-resistant melanoma cells.

物理化学性质&存储条件

分子量	444.863
分子式	C23H19ClF2N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-chlorophenyl)-5,5-difluoro-1-(3-(furan-2-yl)benzoyl)piperidine-3-carboxamide

参考文献

1. Hutchings KM, et al. Bioorg Med Chem Lett. 2017 Apr 15;27(8):1744-1749.

2. Yu-Wai-Man C, et al. Sci Rep. 2017 Mar 31;7(1):518.

3. Sean A. Misek, et al. Abstract 5895: Targeting RhoA-regulated gene transcription in drug-resistant melanoma. AACR 2018.

CCG-222740 (CCG222740)

生物&药学活性

物理化学性质&存储条件

参考文献

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CCG-222740 (CCG222740)

生物&药学活性

物理化学性质&存储条件

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