CCG-203971 | Rho/MKL1/SRF inhibitor | Probechem Biochemicals

Chemical Structure : CCG-203971

CAS No.: 1443437-74-8

加入收藏

CCG-203971 (CCG203971)

货号: PC-62825Not For Human Use, Lab Use Only.

CCG-203971(CCG203971) is a potent Rho/MKL1/SRF transcriptional pathway inhibitor, suppresses PC-3 cell migration in scratch wound assays (IC50=4.2 uM), blocks nuclear localization and activity of MRTF-A in SK-Mel-147 cells.

规格	价格	库存
10 mg	￥580	In stock
25 mg	￥980	In stock
50 mg	￥1580	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

CCG-203971 (CCG203971) is a potent Rho/MKL1/SRF transcriptional pathway inhibitor, suppresses PC-3 cell migration in scratch wound assays (IC50=4.2 uM), blocks nuclear localization and activity of MRTF-A in SK-Mel-147 cells.
CCG-203971 selectively inhibits proliferation of SSc-derived dermal fibroblasts but not that of normal fibroblasts.
CCG-203971 inhibits expression of CTGF, α-SMA, and COL1A2 in SSc fibroblasts as well as in LPA and in TGFβ-stimulated fibroblasts.
CCG-203971 prevents bleomycin-induced skin thickening and collagen deposition in vivo.

物理化学性质&存储条件

分子量	408.88
分子式	C23H21ClN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-chlorophenyl)-1-[3-(2-furanyl)benzoyl]-3-piperidinecarboxamide

参考文献

1. Bell JL, et al. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3826-32.

2. Haak AJ, et al. J Pharmacol Exp Ther. 2014 Jun;349(3):480-6.

3. Haak AJ, et al. Mol Cancer Ther. 2017 Jan;16(1):193-204.

CCG-203971 (CCG203971)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

CCG-203971 (CCG203971)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.