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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-ROCK-CCG-17444
CCG-17444

Chemical Structure : CCG-17444

CAS No.: 303787-04-4

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CCG-17444 (CCG17444)

货号: PC-28451Not For Human Use, Lab Use Only.

CCG-17444 is a small molecule irreversible inhibitor of Shroom3-Rho kinase (ROCK) protein-protein interaction with IC50 opf 12.4 uM, enhances neurite outgrowth in neurons, overcomes growth mediated inhibition by Nogo66.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

CCG-17444 is a small molecule irreversible inhibitor of Shroom3-Rho kinase (ROCK) protein-protein interaction with IC50 opf 12.4 uM, enhances neurite outgrowth in neurons, overcomes growth mediated inhibition by Nogo66.

物理化学性质&存储条件

分子量 359.46
分子式 C17H17N3O2S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

8,8-dimethyl-5-(thiophen-2-yl)-2-thioxo-2,3,5,8,9,10-hexahydropyrimido[4,5-b]quinoline-4,6(1H,7H)-dione

参考文献

1. Dickson HM, et al. BMC Neurosci. 2015 Jun 16;16:34.

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