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首页-小分子抑制剂&激动剂-Others-Other Targets-CCG-1423
CCG-1423

Chemical Structure : CCG-1423

CAS No.: 285986-88-1

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CCG-1423 (CCG1423)

货号: PC-22494Not For Human Use, Lab Use Only.

CCG-1423 (CCG1423) is a small-molecule inhibitor of RhoA transcriptional signaling and serum response factor (SRF), blocks transcription activated by MKL1, disrupts transcriptional responses of the Rho pathway in cancer.

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10 mg ￥680 In stock
25 mg ￥1180 In stock
50 mg ￥1880 In stock
100 mg ￥2880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CCG-1423 (CCG1423) is a small-molecule inhibitor of RhoA transcriptional signaling and serum response factor (SRF), blocks transcription activated by MKL1, disrupts transcriptional responses of the Rho pathway in cancer.
CCG-1423 blocks transcription activated by MKL1, but not that induced by SRF-VP16 or GAL4-VP16.
CCG-1423 inhibits lysophosphatidic acid-induced DNA synthesis in PC-3 prostate cancer cells, and inhibits the growth of RhoC-overexpressing melanoma lines (A375M2 and SK-Mel-147) at nanomolar concentrations.
CCG-1423 is less active on related lines (A375 and SK-Mel-28) that express lower levels of Rho.
CCG-1423 selectively stimulates apoptosis of the metastasis-prone, RhoC-overexpressing melanoma cell line (A375M2) compared with the parental cell line (A375).
CCG-1423 inhibits Rho-dependent invasion by PC-3 prostate cancer cells, wherea it does not affect the Gαi-dependent invasion by the SKOV-3 ovarian cancer cell line.

物理化学性质&存储条件

分子量 454.75
分子式 C18H13ClF6N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-((1-((4-Chlorophenyl)amino)-1-oxopropan-2-yl)oxy)-3,5-bis(trifluoromethyl)benzamide

参考文献

1. Evelyn CR, et al. Mol Cancer Ther. 2007 Aug;6(8):2249-60.

2. Jin W, et al. J Clin Invest. 2011 Mar;121(3):918-29.

3. Evelyn CR, et al. Bioorg Med Chem Lett. 2010 Jan 15;20(2):665-72.

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