CCB02 |CAS:2100864-57-9 Probechem Biochemicals

Chemical Structure : CCB02

CAS No.: 2100864-57-9

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CCB02 (CCB 02)

货号: PC-35881Not For Human Use, Lab Use Only.

CCB02 (CCB 02) is a specific small molecule inhibitor of CPAP-tubulin interaction with IC50 of 0.689 uM in AlphaScreen assay, selectively binds at the CPAP binding site of tubulin.

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10 mg	￥3880	In stock
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生物&药学活性

CCB02 (CCB 02) is a specific small molecule inhibitor of CPAP-tubulin interaction with IC50 of 0.689 uM in AlphaScreen assay, selectively binds at the CPAP binding site of tubulin.
CCB02 does not inhibits a panel of cell cycle- and centrosome-related kinases.
CCB02 impairs proliferation of cells with centrosome amplification, activates extra centrosomes to nucleate enhanced numbers of microtubules prior to mitosis, causes cells to undergo centrosome de-clustering, prolonged multipolar mitosis, and cell death.
CCB02 demonstrates broad anti-invasive activity in various cancer models, including tyrosine kinase inhibitor (TKI)-resistant EGFR-mutant NSCLC.

物理化学性质&存储条件

分子量	235.246
分子式	C14H9N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-methoxybenzo[b][1,6]naphthyridine-4-carbonitrile

参考文献

1. Mariappan A, et al. EMBO J. 2018 Dec 10. pii: e99876. doi: 10.15252/embj.201899876.

CCB02 (CCB 02)

生物&药学活性

物理化学性质&存储条件

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CCB02 (CCB 02)

生物&药学活性

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