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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Xanthine Oxidase (XAO)-CC15009
CC15009

Chemical Structure : CC15009

CAS No.: 2482713-67-5

CC15009 (CC-15009)

货号: PC-22859Not For Human Use, Lab Use Only.

CC15009 is a potent, specific xanthine oxidoreductase (XOR) inhibitor, inhibits XOR-catalyzed uric acid synthesis in vitro with IC50 of 0.237 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

CC15009 is a potent, specific xanthine oxidoreductase (XOR) inhibitor, inhibits XOR-catalyzed uric acid synthesis in vitro with IC50 of 0.237 nM.
CC15009 significantly inhibited liver XOR activity with IC50 of 1.07 nM, inhibits liver xanthine oxidase (XO) and NAD+-dependent xanthine dehydrogenase (XDH) with IC50 of 1.9 nM and 1.06 nM respectively.
CC15009 1 mg/kg shows uric acid-lowering effect in XOR substrate-induced mouse models.

物理化学性质&存储条件

分子量 434.32
分子式 C20H21Cl2N5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-(3-(2,6-dichloro-4-(5-(pyridin-4-yl)-1H-1,2,4-triazol-3-yl)phenoxy)propyl)morpholine

参考文献

1. Xuechen Li, et al. Biomed Pharmacother. 2024 Aug 1:178:117223.

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