CC0651 | Cdc34 inhibitor | Probechem Biochemicals

Chemical Structure : CC0651

CAS No.: 1319207-44-7

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CC0651 (CC 0651, CC-0651)

货号: PC-23077Not For Human Use, Lab Use Only.

CC0651 is a specific, allosteric inhibitor of ubiquitin-conjugating enzyme (E2) Cdc34 with IC50 of 1.72 uM for inhibition of ubiquitination of p27Kip1 by hCdc34.

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1 mg	￥3880	In stock
5 mg	￥7980	In stock
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生物&药学活性

CC0651 is a specific, allosteric inhibitor of ubiquitin-conjugating enzyme (E2) Cdc34 with IC50 of 1.72 uM for inhibition of ubiquitination of p27Kip1 by hCdc34.
CC0651 has effect on activity of oher E2-E3 enzymes, including SMURF2, the Shigella IpaH enzyme SspH1, or the human RING domain enzyme Rnf168.
CC0651 decreases cell proliferation and causes p27Kip1 accumulation in PC-3 cells.
CC0651 engages a composite binding pocket formed from Cdc34A and ubiquitin.
CC0651 also suppresses the spontaneous hydrolysis rate of the Cdc34A-ubiquitin thioester without decreasing the interaction between Cdc34A and the RING domain subunit of the E3 enzyme.

物理化学性质&存储条件

分子量	442.29
分子式	C20H21Cl2NO6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,3S,4S)-5-(3',5'-Dichloro-[1,1'-biphenyl]-4-yl)-2,3-dihydroxy-4-(2-methoxyacetamido)pentanoic acid

参考文献

1. Ceccarelli DF, et al. Cell. 2011 Jun 24;145(7):1075-87.

2. Kleiger G, et al. Nat Chem Biol. 2014 Feb;10(2):156-163.

CC0651 (CC 0651, CC-0651)

生物&药学活性

物理化学性质&存储条件

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CC0651 (CC 0651, CC-0651)

生物&药学活性

物理化学性质&存储条件

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