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首页-小分子抑制剂&激动剂-TGF-beta/Smad-PKC-CC-90005
CC-90005

Chemical Structure : CC-90005

CAS No.: 1799574-70-1

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CC-90005 (CC90005)

货号: PC-72784Not For Human Use, Lab Use Only.

CC-90005 (CC90005) is a potent, selective PKC-θ inhibitor with IC50 of 8 nM, >500-fold selectivity over PKC-γ.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CC-90005 (CC90005) is a potent, selective PKC-θ inhibitor with IC50 of 8 nM, >500-fold selectivity over PKC-γ.
    CC-90005 demonstrated exquisite general kinase selectivity, cellular inhibition of T cell activation as assessed by IL-2 expression.
    CC-90005 exhibited in vivo efficacy in models of acute and chronic T cell activation with oral dosing.

    物理化学性质&存储条件

    分子量 447.491
    分子式 C21H27F2N7O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(((4-(2,2-difluoropropoxy)pyrimidin-5-yl)methyl)amino)-4-(((1R,4S)-4-hydroxy-3,3-dimethylcyclohexyl)amino)pyrimidine-5-carbonitrile

    参考文献

    1. Patrick Papa, et al. J Med Chem. 2021 Aug 26;64(16):11886-11903.

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