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首页-小分子抑制剂&激动剂-Others-CaMK-CC-8977
CC-8977

Chemical Structure : CC-8977

CAS No.: 3032691-65-6

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CC-8977 (CC8977)

货号: PC-21443Not For Human Use, Lab Use Only.

CC-8977 is a hgihly potent, selective inhibitor of calcium/calmodulin-dependent kinase kinase II (CaMKK2) with binding IC50 of 7 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CC-8977 is a hgihly potent, selective inhibitor of calcium/calmodulin-dependent kinase kinase II (CaMKK2) with binding IC50 of 7 nM.
    CC-8977 inhibits phosphorylation of AMPK in LKB1 null A427 cells with IC50 of 170 nM.
    CC-8977 shows CaMKK1 binding IC50 of 26 nM.
    CC-8977 displays high selectivity against a panel of 259 kinases.

    物理化学性质&存储条件

    分子量 362.43
    分子式 C22H22N2O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-cyclopentyl-4-(7-ethoxyquinazolin-4-yl)benzoic acid

    参考文献

    1. Chen Y, et al. J Med Chem. 2023 Dec 14;66(23):15750-15760.

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