CC-671 |CAS:1618658-88-0 Probechem Biochemicals

Chemical Structure : CC-671

CAS No.: 1618658-88-0

加入收藏

CC-671 (CC671;CC 671)

货号: PC-61022Not For Human Use, Lab Use Only.

CC-671 (CC671) is a potent, selective, dual TTK (Mps1)/CLK2 inhibitor with IC50 of 5/3 nM, respectively.

规格	价格	库存
10 mg	￥2580	In stock
25 mg	￥4580	In stock
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

CC-671 (CC671) is a potent, selective, dual TTK (Mps1)/CLK2 inhibitor with IC50 of 5/3 nM, respectively.
CC-671 weakly inhibits DYRK3, DYRK1A, PHKG, DYRK1B, and CLK1 with IC50 of 0.1-0.3 uM, and displays excellent kinase selectivity (7/235 kinases > 80% inhibition at 3 uM).
CC-671 inhibits autophosphorylation of TTK at T686 or phosphorylation of SR protein 75 with IC50 of 0.057 and 0.549 uM in Cal-51 cells.
CC-671 demonstrates strong single agent in vivo efficacy in multiple TNBC xenograft models without significant body weight loss.

物理化学性质&存储条件

分子量	512.57
分子式	C28H28N6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7H-pyrrolo-[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-N-methylbenzamide

参考文献

1. Riggs JR, et al. J Med Chem. 2017 Nov 9;60(21):8989-9002.

CC-671 (CC671;CC 671)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

CC-671 (CC671;CC 671)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.