CC-401 hydrochloride |CAS:1438391-30-0 Probechem Biochemicals

Chemical Structure : CC-401 hydrochloride

CAS No.: 1438391-30-0

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CC-401 hydrochloride (CC 401 hydrochloride;CC401 hydrochloride;CC401 HCl)

货号: PC-43332Not For Human Use, Lab Use Only.

CC-401 hydrochloride is a potent, selective, ATP-competitive pan-JNK inhibitor with Ki of 25-50 nM, displays >40-fold selectivity over other related kinases, including p38, ERK, IKK2, PK C, Lck, and ZAP70.

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10 mg	￥1580	In stock
25 mg	￥2580	In stock
50 mg	￥3780	In stock
100 mg		Get quote

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生物&药学活性

CC-401 hydrochloride is a potent, selective, ATP-competitive pan-JNK inhibitor with Ki of 25-50 nM, displays >40-fold selectivity over other related kinases, including p38, ERK, IKK2, PK C, Lck, and ZAP70.
CC-401 decreases hepatic necrosis and apoptosis after orthotopic liver transplantation in vivo.
CC-401 blocks JNK signaling in the rat obstructed kidney and significantly inhibits renal fibrosis in terms of interstitial myofibroblast accumulation and collagen IV deposition.
CC-401 also significantly reduces tubular apoptosis in the obstructed kidney.
CC-401 sensitizes hypoxic colon cancer cells to DNA-damaging agents, potentiates the effect of bevacizumab and oxaliplatin in HT29-derived mouse xenografts.

物理化学性质&存储条件

分子量	424.9265
分子式	C22H25ClN6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	100 mM in DMSO (42.4 mg/mL)
Chemical Name/SMILES	1H-Indazole, 3-[3-[2-(1-piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-, hydrochloride (1:1)

参考文献

1. Uehara T, et al. Transplantation. 2004 Aug 15;78(3):324-32.

2. Uehara T, et al. J Hepatol. 2005 Jun;42(6):850-9.

3. Ma FY, et al. J Am Soc Nephrol. 2007 Feb;18(2):472-84.

4. Vasilevskaya IA, et al. Clin Cancer Res. 2015 Sep 15;21(18):4143-52.

CC-401 hydrochloride (CC 401 hydrochloride;CC401 hydrochloride;CC401 HCl)

生物&药学活性

物理化学性质&存储条件

参考文献

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CC-401 hydrochloride (CC 401 hydrochloride;CC401 hydrochloride;CC401 HCl)

生物&药学活性

物理化学性质&存储条件

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