Chemical Structure : CC-401
CAS No.: 395104-30-0
货号: PC-63199Not For Human Use, Lab Use Only.
CC-401 (JNK-401) is a potent, selective, ATP-competitive pan-JNK inhibitor with Ki of 25-50 nM, displays >40-fold selectivity over other related kinases.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | ¥1580 | In stock | |
25 mg | ¥2680 | In stock | |
50 mg | ¥3980 | In stock | |
100 mg | Get quote |
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CC-401 (JNK-401) is a potent, selective, ATP-competitive pan-JNK inhibitor with Ki of 25-50 nM, displays >40-fold selectivity over other related kinases.
CC-401 blocks JNK signaling and renal fibrosis in a rat obstructed kidney model, decrease hepatic necrosis and apoptosis after orthotopic liver transplantation and prevent acute renal failure following ischemia/reperfusion associated with renal transplantation in rats.
分子量 | 388.5 | |
分子式 | C22H24N6O | |
外观性状 | Solid | |
储存条件 |
|
|
Solubility |
10 mM in DMSO |
|
Chemical Name/SMILES |
3-[3-[2-(1-piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole |
1. Uehara T, et al. Transplantation. 2004 Aug 15;78(3):324-32.
2. Ma FY, et al. J Am Soc Nephrol. 2007 Feb;18(2):472-84.
3. Kanellis J, et al. Nephrol Dial Transplant. 2010 Sep;25(9):2898-908.
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