CC-401 |CAS:395104-30-0 Probechem Biochemicals

Chemical Structure : CC-401

CAS No.: 395104-30-0

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CC-401 (CC401;JNK-401)

货号: PC-63199Not For Human Use, Lab Use Only.

CC-401 (JNK-401) is a potent, selective, ATP-competitive pan-JNK inhibitor with Ki of 25-50 nM, displays >40-fold selectivity over other related kinases.

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10 mg	￥1580	In stock
25 mg	￥2680	In stock
50 mg	￥3980	In stock
100 mg		Get quote

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生物&药学活性

CC-401 (JNK-401) is a potent, selective, ATP-competitive pan-JNK inhibitor with Ki of 25-50 nM, displays >40-fold selectivity over other related kinases.
CC-401 blocks JNK signaling and renal fibrosis in a rat obstructed kidney model, decrease hepatic necrosis and apoptosis after orthotopic liver transplantation and prevent acute renal failure following ischemia/reperfusion associated with renal transplantation in rats.

物理化学性质&存储条件

分子量	388.5
分子式	C22H24N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[3-[2-(1-piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole

参考文献

1. Uehara T, et al. Transplantation. 2004 Aug 15;78(3):324-32.

2. Ma FY, et al. J Am Soc Nephrol. 2007 Feb;18(2):472-84.

3. Kanellis J, et al. Nephrol Dial Transplant. 2010 Sep;25(9):2898-908.

CC-401 (CC401;JNK-401)

生物&药学活性

物理化学性质&存储条件

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CC-401 (CC401;JNK-401)

生物&药学活性

物理化学性质&存储条件

参考文献

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