CBt-PMN

Chemical Structure : CBt-PMN

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货号: PC-23872Not For Human Use, Lab Use Only.

CBt-PMN is a potent, selective retinoid X receptor (RXR) partial agonist with EC50 of 143 nM (RXRα, Emax = 75%), behaves similarly toward other RXR subtypes.

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生物&药学活性

CBt-PMN is a potent, selective retinoid X receptor (RXR) partial agonist with EC50 of 143 nM (RXRα, Emax = 75%), behaves similarly toward other RXR subtypes.
CBt-PMN shows both PPARγ/RXRα and LXRα/RXRα agonistic activities in vitro.
CBt-PMN exhibits potent glucose-lowering effect and improvements of insulin secretion and glucose tolerance without the serious adverse effects caused by RXR full agonists.

物理化学性质&存储条件

分子量	363.46
分子式	C22H25N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Benzotriazole-5-carboxylic acid, 1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)-

参考文献

1. Kakuta H, et al. ACS Med Chem Lett. 2012 Apr 9;3(5):427-32.

CBt-PMN

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物理化学性质&存储条件

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CBt-PMN

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