CBS1194 | Group 2 IAV inhibitor | Probechem Biochemicals

Chemical Structure : CBS1194

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CBS1194 (CBS 1194)

货号: PC-72694Not For Human Use, Lab Use Only.

CBS1194 is a novel specific fusion inhibitor for group 2 influenza viruses, inhibits IAVs bearing group 2 HAs (pseudo-H7, EC50=0.25 uM).

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生物&药学活性

CBS1194 is a novel specific fusion inhibitor for group 2 influenza viruses, inhibits IAVs bearing group 2 HAs (pseudo-H7, EC50=0.25 uM).
CBS1194 displays no inhibition against both pseudo-H5 and pseudo-Lassa.
CBS1194 exhibitss potency agianst group II influenza viruses influenza A/rhea/North Carolina/1993 (H7N1) and A/Hong Kong/1/1968 (H3N2) with EC59 of 3.17 and 1.60 uM, respectively.
CBS1194 displays no inhibitory activity against group 1 influenza viruses, including A/Puerto Rico/8/1934 (H1N1) and A/Viet Nam/1203/04 (H5N1).
CBS1194 acts at an early stage of viral infection, inhibits viral HA mediated hemolysis, and prevents the low pH-induced conformational change of HA.
The substitutions K1172N and T301A but not D71N to confer resistance to CBS1194.

物理化学性质&存储条件

分子量	451.324
分子式	C22H19BrN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3-bromophenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)-5,7-dimethylimidazo[1,2-a]pyrimidin-3-amine

参考文献

1. Du R, et al. Antiviral Res. 2021 Feb;186:105013.

CBS1194 (CBS 1194)

生物&药学活性

物理化学性质&存储条件

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CBS1194 (CBS 1194)

生物&药学活性

物理化学性质&存储条件

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