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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-CBR417
CBR417

Chemical Structure : CBR417

CAS No.:

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CBR417 (CBR-417)

货号: PC-72980Not For Human Use, Lab Use Only.

CBR417 (CBR-417) is a potent and selective antiwolbachial activity compound (Anti-Wolbachia wMel In vitro HCI cell-based assay IC50=21 nM, IC90=1640 nM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CBR417 (CBR-417) is a potent and selective antiwolbachial activity compound (Anti-Wolbachia wMel In vitro HCI cell-based assay IC50=21 nM, IC90=1640 nM).
    CBR417 demonstrates potent antiwolbachial activity was confirmed in L. sigmodontis, Brugia malayi, and Onchocerca ochengi in vivo preclinical models of filarial disease.
    CBR417 demonstrates in vitro selectivity against Loa loa (a safety concern in endemic areas).

    物理化学性质&存储条件

    分子量 444.384
    分子式 C17H13F5N6OS
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-methyl-2-(3-methyl-1,2,4-oxadiazol-5-yl)-N-(4-(pentafluoro-l6-sulfanyl)phenyl)pyrido[3,4-d]pyrimidin-4-amine

    参考文献

    1. Malina A Bakowski, et al. Sci Transl Med. 2019 May 8;11(491):eaav3523.

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