CBR-470-1

Chemical Structure : CBR-470-1

CAS No.: 2416095-06-0

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货号: PC-24727Not For Human Use, Lab Use Only.

CBR-470-1 is a small molecule inhibitor of glycolytic enzyme phosphoglycerate kinase 1 (PGK1), activates NRF2 signaling in vitro and in vivo.

规格	价格	库存
5 mg	￥580	In stock
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

CBR-470-1 is a small molecule inhibitor of glycolytic enzyme phosphoglycerate kinase 1 (PGK1), activates NRF2 signaling in vitro and in vivo.
CBR-470-1 induces transcript levels of NQO1 and HMOX1, as well as enhances NRF2 protein stabilization in HEK293T, SH-SY5Y, and primary human lung fibroblasts.
CBR-470-1 induces methylglyoxal modification of Keap1, Keap1-Nrf2 disassociation, and increases expression of Nrf2 responsive genes.
CBR-470-1 potently attenuates MPP+-induced oxidative injury and SH-SY5Y cell apoptosis.
CBR-470-1 neuroprotection is dependent upon Nrf2, as Nrf2 shRNA or CRISPR/Cas9-mediated Nrf2 knockout, abolished CBR-470-1-induced SH-SY5Y cytoprotection against MPP+.

物理化学性质&存储条件

分子量	365.89
分子式	C14H20ClNO4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	rel-(3R,4S)-3-((4-Chlorophenyl)sulfonyl)-4-(isobutylamino)tetrahydrothiophene 1,1-dioxide

参考文献

1. Bollong MJ, et, al. Nature. 2018 Oct;562(7728):600-604.

2. Zheng J, et al. Aging (Albany NY). 2020 Jul 10;12(13):13388-13399.

CBR-470-1

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CBR-470-1

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物理化学性质&存储条件

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