CBLC000 | FACT inhibitor | Probechem Biochemicals

Chemical Structure : CBLC000

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CBLC000 (CBL0100)

货号: PC-72241Not For Human Use, Lab Use Only.

CBLC000 (CBL0100) is a small molecule histone chaperone FACT inhibitor, activates p53 and inhibits NF-κB with EC50 of 0.06 and 0.03 uM in cell-based p53 and NF-κB reporter assays, respecitvely.

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生物&药学活性

CBLC000 (CBL0100) is a small molecule histone chaperone FACT inhibitor, activates p53 and inhibits NF-κB with EC50 of 0.06 and 0.03 uM in cell-based p53 and NF-κB reporter assays, respecitvely.
CBLC000 blocks emergence of iPSC colonies from primary MEFs, does not affect either the growth or undifferentiated state of established pluripotent cells.

物理化学性质&存储条件

分子量	374.484
分子式	C24H26N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(2-(diethylamino)ethyl)-1,6,10,11-tetrahydro-3H-dicyclopenta[c,g]carbazole-3,9(2H)-dione

参考文献

1. Alexander V Gasparian, et al. Sci Transl Med. 2011 Aug 10;3(95):95ra74.

2. Zuolian Shen, et al. Stem Cells Dev. 2018 Dec 15;27(24):1693-1701.

CBLC000 (CBL0100)

生物&药学活性

物理化学性质&存储条件

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CBLC000 (CBL0100)

生物&药学活性

物理化学性质&存储条件

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