CBK288679 | Autophagy inhibitor | Probechem Biochemicals

Chemical Structure : CBK288679

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CBK288679 (CBK79)

货号: PC-72577Not For Human Use, Lab Use Only.

CBK288679 (CBK79) is a novel compound that impairs both protein degradation by the ubiquitin-proteasome system (UPS) and autophagy.

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生物&药学活性

CBK288679 (CBK79) is a novel compound that impairs both protein degradation by the ubiquitin-proteasome system (UPS) and autophagy.
CBK79 inhibits cell viability of MelJuSo Ub-YFP cells with 72h IC50 of 0.22 uM, CBK79-inflicted cell death was caspase-independent.
CBK79 causes accumulation of ubiquitin-dependent and -independent proteasome substrates.
CBK79 induces non-canonical lipidation of MAP1LC3B/LC3B (microtubule-associated protein 1 light chain 3 beta) that requires ATG16L1 but is independent of the ULK1 and class III phosphatidylinositol 3-kinase (PtdIns3K) complexes.
CBK79 (10 uM) induces proteotoxic stress and the heat shock response in HOS GFP-LC3B cells.
CBK79 has unique features as it inhibits both ubiquitin-dependent and -independent degradation of short-lived proteins by the UPS, as well as the degradation of long-lived proteins by autophagy.

物理化学性质&存储条件

分子量	282.365
分子式	C15H14N4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3- methyl-N-[4-(3-methylpyridin-2-yl)-1,3-thiazol-2-yl]pyridin2-amine

参考文献

1. Giovannucci TA, et al. Autophagy. 2021 Nov 5:1-17. doi: 10.1080/15548627.2021.1988359.

CBK288679 (CBK79)

生物&药学活性

物理化学性质&存储条件

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CBK288679 (CBK79)

生物&药学活性

物理化学性质&存储条件

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